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Combine the ketchup, paprika, horseradish, dry mustard, salt and cayenne in a mixing bowl. Fold in the aioli, and mix well.
For the po'boy: Heat the oil in a medium saucepot until it reaches 350 degrees F on a deep-fry thermometer.
Lightly bread the shrimp and oysters by tossing in the breading mix. Carefully add the seafood to the hot oil, working in batches if necessary. Cook until golden brown and cooked through, 3 to 5 minutes.
Toast the hoagie rolls. To the toasted rolls add the lettuce, tomato and red onion, and then drizzle remoulade sauce over the vegetables. Top with the fried shrimp and oysters, and serve with lemon wedges.