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For the seasoned beef: Trim the brisket of excess fat. Mix together the salt, black pepper, granulated garlic and cayenne in a bowl, then rub the meat with the spices.
For the guru dust: In a small bowl, mix together the smoked paprika, chili powder, salt, granulated sugar, black pepper, onion powder, turbinado sugar, oregano and thyme. Rub the mixture into the meat.
Smoke the brisket for 90 minutes per pound, about 12 to 16 hours total, rotating the brisket every 2 hours. When an internal temperature of 190 degrees F is reached, remove the brisket to a cutting board and slice it on the bias. Arrange the meat on a serving platter and serve with the artisan bread.